**0**wrote:

Is there a way to use ComBat to return a data matrix adjusted by only numeric covariates? As implemented in SVA, ComBat allows for adjustment of data by numeric covariates, but only if a batch effect (i.e., a factor variable) is also provided. What if I just want to "clean" a data matrix of several continuous, numeric nuisance variables (e.g., surrogate variables as identified by SVA)? Specification of the nuisance variables in a linear model is not possible, as I am attempting to apply k-means clustering to the data.

**730**• written 6 weeks ago by JMallory •

**0**