gene expression baseline adjustment for pre/post treatment
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Jun Xu ▴ 10
@jun-xu-1409
Last seen 9.6 years ago
Hi, All, We have an experiment in which 30 subjects were divided into two groups (15 treatment and 15 control). Gene expressions were measured before and after treatment for both groups. I am wondering what is the best way to do baseline adjustment? Several ways of analysis are in consideration. 1. Post treatment gene expression only. 2. Difference in Post/pre treatment 3. ANCOVA using baseline gene expression as covariate for each gene. Any suggestion? If using ANCOVA, is it required to use the parallel line model? Thanks Jun
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