Question: How to define the top 100 hub genes in each module and find out the genes having direct connections with hub genes
gravatar for wangdp123
17 months ago by
wangdp1230 wrote:

Dear Colleague,

1. I am using the WGCNA software to construct a gene co-expression network and identify several modules. The aim is to find out the top 100 hub genes for each module. I only find a function called chooseTopHubInEachModule which is able to find one top hub gene for each module.

In my case, do you have some advice on how to get the top 100 hub genes for each module in a straightforward way? Any function or any code?


2. After discovering the hub genes, I would like to research for the genres that have direct connections with those hub genes. Any suggestions for this step?

Many thanks for your help,





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