> Hi, ChAMP was installed in R, however, I can't  load the function. ChAMPdata could be used.

library("ChAMP")
Error: package or namespace load failed for 'ChAMP' in dyn.load(file, DLLpath = DLLpath, ...):
 unable to load shared object '/Library/Frameworks/R.framework/Versions/3.4/Resources/library/mvtnorm/libs/mvtnorm.so':
  `maximal number of DLLs reached...
In addition: Warning messages:
1: replacing previous import 'plyr::summarise' by 'plotly::summarise' when loading 'ChAMP' 
2: replacing previous import 'plyr::rename' by 'plotly::rename' when loading 'ChAMP' 
3: replacing previous import 'plyr::arrange' by 'plotly::arrange' when loading 'ChAMP' 
4: replacing previous import 'plyr::mutate' by 'plotly::mutate' when loading 'ChAMP' 

Hello:

The reason is R does not allow users to load more than 100 DLL. large packages like ChAMP would load many dependence packages, and these dependences would also load many other packages.

I am now fixing this issue, but it's challenging because I need to decrease some relying packages maybe. A quick solution for you is that you can reset your Renviron file and add one line: R_MAX_NUM_DLLS=512, then this error should be no more.

On user level, the .Renviron file could be find(created) in your home directory.

On system level, The Renviron file should be at /usr/local/lib64/R/3.4.4/lib64/R/etc (on my linux server).

(Also, I suggest you restart your R session, then try load ChAMP, so that you can unload all other packages.)

Best

Yuan Tian

Dear Yuan and Martin:

Thank you very much. I used R.home("etc")  to find the location and revise the Renviron file. Then Rstudio collapsed. We revised it to "R_MAX_NUM_DLLS=150". Now it works. Report to you.

Best,

Tao