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Question: Study Modules significance (or Modules Preservation) in ONE network
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gravatar for harelarik
5 months ago by
harelarik0
harelarik0 wrote:

Hi,

 

I am studying only one co-expression network utilizing WGCNA.

I would like to validate that the modules identified by WGCNA are significantly above randomly generated modules.

 

1. What would be the best way to do it?

2. Is there a way to utilize the modulePreservation function to study preservation of modules only in one network?

It looks like the modulePreservation function was designed to do more complicated analysis. To study preservation of modules between two (or more) networks. It also uses randomized data to asses the significance of the results. Maybe there is a way to use it only for one network?

 

 

Thank you!

 

 

ADD COMMENTlink modified 5 months ago • written 5 months ago by harelarik0

I was advised that it is possible to use modulePreservation with a single data set. Single set can be supplied both as reference, and as a test set. I the results, one should focus on module quality.

ADD REPLYlink modified 5 months ago • written 5 months ago by harelarik0
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