Hi! I am running Bioconductor on WindowsXP and can do just one job at a time. When I've submitted another job my machine got memory problem (I have 1G of RAM though). I am exiting Bioconductor and open it again. Memory problem is fixed by this (is there hanging pointers somewhere?) but affy library is screwed. This what I have: Error in mlistMetaName(f) : No way to associate a generic function with an object of class "NULL" Error in library(affy) : .First.lib failed The only way I can fix it is to reinstall whole package again. Is there Uninstall function for Bioconductor, which will not uninstall R? How to fix described problem? How much memory should I have to run 33 U133 chips at once? Thank you Dmitry N. Grigoryev, M.D., Ph.D. Data Analyst Gene Expression Profiling Core Division of Pulmonary and Critical Care Medicine Johns Hopkins University School of Medicine

> Hi! > I am running Bioconductor on WindowsXP and can do just one job at a time. When I've submitted another job my machine got memory problem (I have 1G of RAM though). I am exiting Bioconductor and open it again. Memory problem is fixed by this (is there hanging pointers somewhere?) but affy library is screwed. > This what I have: > > Error in mlistMetaName(f) : No way to associate a generic function with an object of class "NULL" > Error in library(affy) : .First.lib failed For this sort of thing you have to tell us the versions of the various tools you are working with: What version of R, which version of affy, etc. The errors above have to do with the methods package of R which is evolving independently of affy. > > The only way I can fix it is to reinstall whole package again. this is overkill. you have to provide more precise diagnostic information to solve the problem rationally. > > Is there Uninstall function for Bioconductor, which will not uninstall R? > How to fix described problem? no. but you could use Rcmd REMOVE [pkgname] from a windows DOS prompt if you had Rcmd.exe in your path.