I want to do differential exon usage analysis with DEXseq. I have 3 affected (2 technical replicates for each individual, so 6 samples total) and 3 unaffected individuals (also 2 technical reps for each sample, 6 samples overall). My question is how should I take into account technical replicates in this experiment with DEXseq? Should I add it in the formula somehow? And how my metadata table should look like in this case?