Question: A question about log_transformed
gravatar for liushang
16 months ago by
liushang0 wrote:

I would like you to tell me why the filtered expression matrix M should log-transformed after adding a pseudo-count of 1: M’ = log2(M + 1).

Thank you!!

sc3 • 224 views
ADD COMMENTlink modified 16 months ago by James W. MacDonald51k • written 16 months ago by liushang0
Answer: A question about log_transformed
gravatar for James W. MacDonald
16 months ago by
United States
James W. MacDonald51k wrote:

Adding a pseudo-count prior to taking logs protects against taking logs of zero. In addition, if you have lots of really small counts it can also help reduce the variability inherent in having small counts, particularly if you use a larger prior count.

ADD COMMENTlink written 16 months ago by James W. MacDonald51k
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