Recently, I am using DESeq2 for differential analysis of proteomics data. But I got an error:
invalid class “DESeqDataSet” object: NA values are not allowed in the count matrix
I checked my input table, it contains no "NA".
Afterwards, I found that somebody had a similar error as mine ( DESeq2 Error NA values ). Based on the response in this post, I also found out my input table contains some values which are higher than 10 billion. Thus, I do a normalization to reduce the number of values. Then, the error is gone, and I got the results.
I would like to confirm that does DESeq2 not accept the values which is extremely high? But this kind of high value is quite common in the intensity of proteomics.