I have a question about DESEQ2 data normalization. I know that DESEQ2 requires raw reads counts, that the softwares normalizes by seq depth.
But what if I want to account for technical variation? Normally, I would quantile-normalize the data, but I understand that DESEQ2 does not support quantile normalized data, so how can I correct for this kind of variability?
Thanks in advance,