Hi fellow DESeq'ers!
I am trying to figure out how to model a DEA with n paired samples (so n conditions + n controls, where the two sample sets come from the same individuals) plus two unrelated controls. So overall I am dealing with n condition + n+2 controls.
From the DESeq2 Vignette I could read that a paired experiment should be modeled as ~subject+condition, but I am wondering if this could work in my case as well.
Many many thanks in advance!