I'd like to annotate a set of variants I called by other methods outside R and BioC. After looking into some tutorials, I lean towards locateVariants function within the VariantAnnotation package. However, I've seen its second argument must be a TxDb object, which is intended for transcripts, and not any genomic region (is this correct???). If I am interested n variants lying on any region of the genome (transcripts or not), shouldn't I use other method? If I unterstood wrong and TxDb objects contain all regions of the genome, then the problem would be solved.