Typo / Mistyped in rWikipathways - 4. Pathway Analysis? (GSEA) / NES <-1 instead of NES < 1 for downregulated genes
1
2
Entering edit mode
@fischer-philipp-18490
Last seen 23 months ago
Austria

Hey everyone,

I was reading the documentation of rWikipathways( check link below) when I think I encountered a typo. 

https://bioconductor.org/packages/release/bioc/vignettes/rWikiPathways/inst/doc/Pathway-Analysis.html

After running GSEA() one is to distinguish which pathways are enriched for upregulated and which for downregulated genes. 

The following code is a copy of the assumed typo.

4.WikiPathways

gwp.sig.lung.expr.df[which(gwp.sig.lung.expr.df$NES>1),] #pathways enriched for upregulated lung cancer genes  (1) gwp.sig.lung.expr.df[which(gwp.sig.lung.expr.df$NES<1),] #pathways enriched for downregulated lung cancer genes (2)

In code line (2): Shouldn't it be ...$NES < -1 instead of $NES < 1?

Thanks for your answers.

typo NES rwikipathways downregulated genes gene set enrichment analysis • 847 views
ADD COMMENT
0
Entering edit mode
alex.pico ▴ 20
@alexpico-15339
Last seen 3 months ago
United States

Yes. This has been fixed and will be in the next release at the end of the month. Thanks for catching this!

ADD COMMENT

Login before adding your answer.

Traffic: 614 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6