scATAC-seq analysis, data preprocessing
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chipolino • 0
@chipolino-15565
Last seen 4.4 years ago

Hi,

During scATAC-seq data preprocessing, does it make sense to filter data matrix, so it contains only most variable peaks (in the same way how we do it for scRNA-seq), before any further dimensionality reduction or clustering analysis?

Thanks

scATAC-seq • 748 views
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Cross-posted on Biostars as suggested by Aaron.

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Aaron Lun ★ 28k
@alun
Last seen 10 hours ago
The city by the bay

You're not asking about a specific Bioconductor package; a general question should be posted on a more general forum like Biostars. But for what it's worth, the answer is: probably yes.

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