HI, WE ARE TRYING TO INSTALL AFFY PACKAGE AND BIOC ON A IMAC WITH OS10 AND WHEN WE TRY TO READ A CEL FILE HERE IS WHAT WE GET: > library(affy) Welcome to Bioconductor To view some introductory material -- look at our vignettes Simply type: openVignette() to see the available vignettes To read a vignette see the openVignette help page for details Creating a new generic function for "summary" in package Biobase Attaching package `Biobase': The following object(s) are masked from package:base : split summary Attaching package `affy': The following object(s) are masked from package:base : barplot boxplot colnames hist history image ncol nrow > Data <- ReadAffy() Error in getInfoInAffyFile(filename, "CEL", "HEADER", "DatHeader", compress = compress) : Cannot open the file Wilson:Applications:rm162::0126192.CEL. SO IT SEEMS THAT BIOC IS ABLE TO GET AFFY WORKING BUT READNG THE CEL FILE SEEMS T BE A TROUBLE. WE ARE RUNNING BIOC on R1.6.2 and the Affy package is the routine one, not the developmental package. ANY HELP WELCOME ! THANKS Derek L. Stirewalt, MD Associate in Clinical Research D4-100, FHCRC 1100 Fairview Ave N Seattle, WA 98109 (206)-667-5113