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@weichen-cls-23902
Last seen 4.4 years ago
Recently,I am working on a project about DNA methylation of Cord Blood and RRBS was applied.However, available version of methylCCis only suitable for Peripheral Blood since FlowSorted.Blood.450k but not FlowSorted.CordBlood.450k is used as reference. Is there any way to apply or modify methylCC for Cord Blood? Any suggestions would be appreciated!
Hi,
Unfortunately, I don't know of a way to do that at the moment. The software would need to be adapted to a different a different reference dataset. I plan on making some updates to this package in the Fall 2020 and could think more about how to make this package more flexible to alternative reference datasets. Thank you for the suggestion!
All the best, Stephanie
Also, I've opened up a GitHub issue to make sure to get back to this in the fall. Feel free to following along with the conversation there. https://github.com/stephaniehicks/methylCC/issues/4