I was wondering what the value of the slope I am running wgcna with 150 samples/~4000 genes.
My r2 value plateus from 10 onwards with a value of 0.92+
At 10 the slope is -8.9 At 12 the slope is -5.5 At 14 the slope is -3.47 It then drops to -2 and then stays between -1 and -2.
I understand the slope should be negative. I've also read that it should be around -1. I don't understand if/why -1 is better than say -9.
But also if slope is changing so much does that mean the thresholding powers are not that stable