Question: when to impute the missing value?
11.3 years ago by
De-Jian ZHAO • 240
De-Jian ZHAO • 240 wrote:
Dear all, Microarray experiments easily have missing values. The R packages impute and pcaMethods both can impute the missing values. I wonder at which step we carry out the imputation. After reading data into R? Before normalization? Ater finding the differentially expressed genes? When required to do so,e.g. PCA and SVD? ... Thank you for any advice. Zhao
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