Entering edit mode
william ritchie
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20
@william-ritchie-2747
Last seen 9.6 years ago
Dear Bioc community,
I have a little question about combining p-values with stouffers
method.
One of the conditions for combining p-values is that each test be
considered as independent.
If I was interested in a group of say, 10 genes and I wanted to know
if, as a group, they were significantly over or under expressed, would
it be correct to combine the p-values (calculated from a series of
microarrays) for each individual gene using stouffers method to be
able to conclude that this group of genes is differentially expressed
?
Thanks,
william.
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