Dear all, I wonder if anyone has implemented or is intentioned to implement the procedure described in Peddada et al. "Gene selection and clustering for time-course and dose-response microarray experiments using order- restricted inference" in the Bioconductor or R environment. If not, do you know if there are other packages avalaible for R dealing with order restricted inference? Lastly, I would appreciate any suggestions of other approches to classify conveniently time profiles. Thank you in advance. Best wishes, Stefano.