This is an off-topic posting, but I thought it might be of interest to some members on this list. The Collaborative Network for Clinical Research on Immune Tolerance (Immune Tolerance Network - ITN) is an NIH funded initiative to facilitate the advancement of immune tolerance inducing procedures in human clinical practice, towards the development of new and improved treatment, and monitoring protocols in kidney and islet transplantation, autoimmune disease, and asthma and allergic diseases. The ITN, which combines the expertise of over 70 scientists and clinicians from fifty institutions both in the US and abroad, will develop new therapies in five broad areas and test these new interventions in Phase I/II clinical trials. With more than $20 million dollars in funding per year, the Network is responsible for all aspects of the implementation of the clinical trials and mechanistic studies. Working closely with clinicians, statisticians, biologists and bioinformaticans, the incumbent will provide statistical consultancy and guidance in experimental design and approaches to analyzing data to the functional areas of the Immune Tolerance Network (ITN). The incumbent will contribute to the development of novel methods, as well as the application of these and existing methods, to solve complex problems in genomics, proteomics and statistical genetics. An initial area of focus will be gene expression analysis. Required qualifications for this position include a PhD with 2+ years experience. or Master degree with 5+ years experience in Statistics, Mathematics, or related field; Knowledge of advanced statistical methods; Solid background and experience using statistical approaches to analyze large data sets; Experience with parametric and non-parametric tests; Understanding of supervised and unsupervised clustering algorithms; Knowledge of microarray technology is helpful. Ability to clearly communicate ideas and results of analyses with researchers of various backgrounds; Ability to work well in a team environment; Excellent organizational and computer skills. Excellent written and verbal communications skills. Programming skills in R, S-PLUS, or SAS; Some biology background are preferred. Experience with Affymetrix technology is a plus; Knowledge of programming languages (C/C++, Java, Perl) is a plus. Detailed Description of Duties: 30% Provide statistical design leadership for ITN's tolerance assay programs by applying technical expertise and knowledge to complex experiments designed to generate new scientific data. Direct the design of basic research studies designed to advance the understanding of the underlying mechanisms of immunomodulatory and tolerogenic approaches conducted by the ITN. Responsibilities include selection of appropriate statistical techniques such as calculation of sample size requirements for statistical significance, selection of randomization and stratification methods, definition of immune/surrogate markers and assessing the feasibility of recruiting and retaining adequate numbers of patient samples. Coordinate with CROs to ensure consistent design of databases for appropriate analysis relating to mechanistic studies. Provide general oversight of the CRO's statistical work so that standards are followed across all ITN trials as they relate to mechanistic portions of the trials. Help set up ITN standards for statistical reports (tables, listings, figures, etc) and standards for statistical analyses. These analyses will include reports for DSMB, IRB, and FDA submissions. Ensure effective design of study forms in collaboration with ITN Clinical trials Group and ITN Investigators. 40 % Research and Development Analyze new techniques and methodologies in comparison with standard approaches. Modify and improve experimental set-up to ensure quality control Research and develop new techniques for the performance of or more efficient experiments. 30% Analysis and Reporting Lead efforts to integrate and analyze a diversity of data, including clinical phenotype data combined with gene expression, flow cytometry, tetramer, tissue, ELLISPOT and genotype data. Participate on project teams by communicating experimental findings or results and providing technical expertise. Prepare interim and final analyses of: validity, reliability and specificity of techniques and methodologies used in performing assays; Present analyses and recommendations to the ITN Steering Committee and assist in implementing necessary modifications approved by the Steering Committee, including revised research designs for mechanistic studies. Assist in preparation for abstract presentations at scientific meetings; manuscript preparation and study final report preparation. Send CV to Jess Landis. jlandis@immunetolerance.org Position is located in Bethesda, MD CONFIDENTIALITY NOTICE This communication and any attachment...{{dropped}}