clippda is a package for the clinical proteomic profiling data analysis. The datasets of interest arise from studies using the mass spectrometry technologies, such as SELDI and MALDI. The focus is on the studies of human subjects, which are often observational case-control by design and the peak data is produced in technical replicates. A method for sample size determination for planning these studies is given. It incorporates routines for adjusting for the expected heterogeneities and imbalances in the data and the within-sample replicate correlations. You may access it through the commands: > source("http://bioconductor.org/biocLite.R") > biocLite("clippda") The package homepage is URL: http://www.cancerstudies.bham.ac.uk/crctu/CLIPPDA.shtml Kind regards Stephen