Dear all, Currently£¬we are working with Affymetrix u133plus2 array and interested in classification disease/control using microarray data. We have identified a molecular signature and trained a svm-based classification model based on 200 samples (100 disease +100 control). We are satisfied with the model performance (sensibility/specificity) evaluated with cross validation process. Now we are planning to evaluate the model performance on an independent dataset. I have been asked to estimate sample size required for a given target sensibility/specificity. So I would like to know is there any general approach (paper or software) existed to deal with sample size estimation for independent validation set. Any help will be greatly appreciated, Thanks in advance, Qinghua ---------------------------------------------------------------------- ------- AVIS : Ce courrier et ses pieces jointes sont destines a leur seul destinataire et peuvent contenir des informations confidentielles appartenant a bioMerieux. Si vous n'etes pas destinataire, vous etes informe que toute lecture, divulgation, ou reproduction de ce message et des pieces jointes est strictement interdite. Si vous avez recu ce message par erreur merci d'en prevenir l'expediteur et de le detruire, ainsi que ses pieces jointes. NOTICE: This message and attachments are intended only for the use of their addressee and may contain confidential information belonging to bioMerieux. If you are not the intended recipient, you are hereby notified that any reading, dissemination, distribution, or copying of this message, or any attachment, is strictly prohibited. If you have received this message in error, please notify the original sender immediately and delete this message, along with any attachments. [[alternative HTML version deleted]]

Dear all,  Currently，we are working with Affymetrix u133plus2 array and interested in classification disease/control using microarray data.  We have identified a molecular signature and trained a svm-based classification model based on 200 samples (100 disease +100 control). We are satisfied with the model performance (sensibility/specificity) evaluated with cross validation process. Now we are planning to evaluate the model performance on an independent dataset.  I have been asked to estimate sample size required for a given target sensibility/specificity. So I would like to know is there any general approach (paper or software) existed to deal with sample size estimation for independent validation set.  Any help will be greatly appreciated,  Thanks in advance, Qinghua ___________________________________________________________ å¥½çŽ©è´ºå¡ç­‰ä½ å‘ï¼Œé‚®ç®±è´ºå¡å ¨æ–°ä¸Šçº¿ï¼ [[alternative HTML version deleted]]