Marc Carlson <mcarlson at="" ...=""> writes: > > Hi Manikhandan, > > I still cannot reproduce this problem. I have loaded all the latest > versions of the packages that you have in your sessionInfo() and none of > them causes any problems for me. But the error says that your > annotation database is locked. And so I wonder if you might have other > R sessions (or other things) open which are tapping into (and possibly > writing to) this same library? So you might want to start over, and be > sure to try and kill any rogue R processes that may be present, it might > also be a good idea to start fresh by moving the .RData file from the > directory you use to launch R. Another thing to try is to remove your > previous annotation packages (in particular org.Hs.eg.db since that one > is giving this error) with remove.packages(). That way you can get a > fresh start when you try to use biocLite() to install these packages. > > Marc > Dear Marc, Thanks for your time and efforts. It is not working. I have tried many times (rebooting, launching R from different directories, starting new sessions, etc). I have no other R sessions running. remove.packages("org.Hs.eg.db") reports that no such packages in my library. Thanks. Best Regards, Mani