Entering edit mode
Jitao David Zhang
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340
@jitao-david-zhang-3188
Last seen 7.7 years ago
Hi dear Pierre and Robert,
Sorry to be so late getting back, and it is a shame that I actually
missed your last emails! I will make the modifications right soon and
update
you then.
Thank you very much for the debugging work and suggestions!
Best wishes,
David
2010/9/21 Pierre Neuvial <pierre@stat.berkeley.edu>
> Hi David,
>
> Has there been any follow-up on this ? I bumped into the same error
as
> Robert.
>
> You asked for the file he used. If you run the code sent by Robert,
> you will get
>
> > keggID <- "05213"
> > tmpXML <- "testKGML1.xml"
> > retrieveKGML(pathwayid=keggID, organism='mmu', destfile=tmpXML,
> method="wget")
> --2010-09-21 12:23:04--
>
> ftp://ftp.genome.jp/pub/kegg/xml/kgml/non-
metabolic/organisms/mmu/mmu05213.xml
> =>
> `/var/folders/R7/R7TMUh6WGeSJE0LtxqwHWk+++TI/-Tmp-//RtmpmGNCWB/file1
eaf6b0f'
> Resolving ftp.genome.jp... 133.103.100.184
> Connecting to ftp.genome.jp|133.103.100.184|:21... connected.
> Logging in as anonymous ... Logged in!
> ==> SYST ... done. ==> PWD ... done.
> ==> TYPE I ... done. ==> CWD
> /pub/kegg/xml/kgml/non-metabolic/organisms/mmu ... done.
> ==> SIZE mmu05213.xml ... 16729
> ==> PASV ... done. ==> RETR mmu05213.xml ... done.
> Length: 16729 (16K)
>
> 100%[======================================>] 16,729 38.4K/s
in 0.4s
>
> 2010-09-21 12:23:07 (38.4 KB/s) -
>
> `/var/folders/R7/R7TMUh6WGeSJE0LtxqwHWk+++TI/-Tmp-//RtmpmGNCWB/file1
eaf6b0f'
> saved [16729]
>
> --2010-09-21 12:23:07--
>
> ftp://ftp.genome.jp/pub/kegg/xml/kgml/non-
metabolic/organisms/mmu/mmu05213.xml
> => `testKGML1.xml'
> Resolving ftp.genome.jp... 133.103.100.184
> Connecting to ftp.genome.jp|133.103.100.184|:21... connected.
> Logging in as anonymous ... Logged in!
> ==> SYST ... done. ==> PWD ... done.
> ==> TYPE I ... done. ==> CWD
> /pub/kegg/xml/kgml/non-metabolic/organisms/mmu ... done.
> ==> SIZE mmu05213.xml ... 16729
> ==> PASV ... done. ==> RETR mmu05213.xml ... done.
> Length: 16729 (16K)
>
> 100%[======================================>] 16,729 44.2K/s
in 0.4s
>
> 2010-09-21 12:23:09 (44.2 KB/s) - `testKGML1.xml' saved [16729]
>
> That should be enough for you to reproduce the error. If not, the
file is
> here:
>
>
> ftp://ftp.genome.jp/pub/kegg/xml/kgml/non-
metabolic/organisms/mmu/mmu05213.xml
>
> I've investigated this issue a bit more. The problem comes from the
> fact that this KEGG pathway (as well as a fair proportion of KEGG
> pathways) has at least one edge whose label is not understood by
> KEGGgraph, in this case (quoted from the above KGML file):
>
> <relation entry1="20" entry2="25" type="PCrel">
> <subtype name="missing interaction" value="-/-"/>
> </relation>
>
> The types of interaction known by KEGGgraph are retrieved from a
data
> object from the package:
>
> > data(KEGGEdgeSubtype, package="KEGGgraph")
> > as.character(KEGGEdgeSubtype[["name"]])
> [1] "compound" "hidden compound" "activation"
> [4] "inhibition" "expression" "repression"
> [7] "indirect" "indirect effect" "state change"
> [10] "binding/association" "dissociation" "phosphorylation"
> [13] "dephosphorylation" "glycosylation" "ubiquitination"
> [16] "methylation"
>
> Because "missing interaction" is not known, the above error occurs.
> An easy fix for this problem is to add a line with name=="missing
> interaction" to this data.frame, and re-build the package.
>
> I've also encountered another instance of the same problem:
>
> > keggID <- "05213"
> > tmpXML <- "testKGML2.xml"
> > retrieveKGML(pathwayid=keggID, organism='mmu', destfile=tmpXML,
> method="wget")
> --2010-09-21 13:56:37--
>
> ftp://ftp.genome.jp/pub/kegg/xml/kgml/non-
metabolic/organisms/mmu/mmu05213.xml
> =>
> `/var/folders/R7/R7TMUh6WGeSJE0LtxqwHWk+++TI/-Tmp-//RtmpmGNCWB/file1
3f877e9'
> Resolving ftp.genome.jp... 133.103.100.184
> Connecting to ftp.genome.jp|133.103.100.184|:21... connected.
> Logging in as anonymous ... Logged in!
> ==> SYST ... done. ==> PWD ... done.
> ==> TYPE I ... done. ==> CWD
> /pub/kegg/xml/kgml/non-metabolic/organisms/mmu ... done.
> ==> SIZE mmu05213.xml ... 16729
> ==> PASV ... done. ==> RETR mmu05213.xml ... done.
> Length: 16729 (16K)
>
> 100%[======================================>] 16,729 41.4K/s
in 0.4s
>
> 2010-09-21 13:56:39 (41.4 KB/s) -
>
> `/var/folders/R7/R7TMUh6WGeSJE0LtxqwHWk+++TI/-Tmp-//RtmpmGNCWB/file1
3f877e9'
> saved [16729]
>
> --2010-09-21 13:56:39--
>
> ftp://ftp.genome.jp/pub/kegg/xml/kgml/non-
metabolic/organisms/mmu/mmu05213.xml
> => `testKGML2.xml'
> Resolving ftp.genome.jp... 133.103.100.184
> Connecting to ftp.genome.jp|133.103.100.184|:21... connected.
> Logging in as anonymous ... Logged in!
> ==> SYST ... done. ==> PWD ... done.
> ==> TYPE I ... done. ==> CWD
> /pub/kegg/xml/kgml/non-metabolic/organisms/mmu ... done.
> ==> SIZE mmu05213.xml ... 16729
> ==> PASV ... done. ==> RETR mmu05213.xml ... done.
> Length: 16729 (16K)
>
> 100%[======================================>] 16,729 58.8K/s
in 0.3s
>
> 2010-09-21 13:56:42 (58.8 KB/s) - `testKGML2.xml' saved [16729]
>
> > tmpGraph2 <- parseKGML2Graph(tmpXML, genesOnly=FALSE)
> > plotKEGGgraph(tmpGraph2)
> Error in .subtypeDisplay(object) :
> Given subtype 'ubiquination' is not found!
>
> This actually comes from a typo in KEGG entries: ubiquitination has
> been misspelled as "ubiquination" in
>
> ftp://ftp.genome.jp/pub/kegg/xml/kgml/non-
metabolic/organisms/mmu/mmu05213.xml
> (and a bunch of other KEGG files too).
>
> Again, this can be fixed by adding a line with name=="ubiquination"
to
> KEGGEdgeSubtype.
> I've done this locally: edited the file
> KEGGgraph/data/KEGGEdgeSubtype.csv, recompiled the KEGGgraph
package,
> and it works with no error.
>
> David, could you do this kind of fix ?
>
> More generally, it would of course be much better if the
> .subtypeDisplay function did not throw an *error* but a *warning*
when
> encountering unknown interaction names.
>
> Hope this helps,
>
> Pierre
>
> R version 2.11.1 Patched (2010-09-16 r52946)
> Platform: x86_64-apple-darwin9.8.0/x86_64 (64-bit)
>
> locale:
> [1] en_US.UTF-8/en_US.UTF-8/C/C/en_US.UTF-8/en_US.UTF-8
>
> attached base packages:
> [1] grid stats graphics grDevices datasets utils
methods
> [8] base
>
> other attached packages:
> [1] KEGGgraph_1.5.0 Rgraphviz_1.26.0 graph_1.26.0 XML_2.8-1
> [5] R.utils_1.5.2 R.oo_1.7.3 R.methodsS3_1.2.0
fortunes_1.3-7
>
> loaded via a namespace (and not attached):
> [1] tools_2.11.1
>
> On Wed, Jul 21, 2010 at 2:31 PM, Jitao David Zhang
> <davidvonpku@gmail.com> wrote:
> > Hi dear Robert,
> >
> > Thanks for reporting! Would you please send the file you used? I
will
> try
> > to figure out what went wrong.
> >
> > Best wishes,
> > David
> >
> > 2010/7/7 Robert M. Flight <rflight79@gmail.com>
> >
> >> Hi All,
> >>
> >> I'm playing around with KEGGGraph to examine some pathways, and I
am
> >> running into some errors.
> >>
> >> When I try to plot some pathways, I get the error: "Error in
> >> .subtypeDisplay(object) : Given subtype 'missing interaction' is
not
> >> found!"
> >>
> >> Here is an example with one pathway that gives the error and
another
> >> that does not:
> >>
> >> library(KEGGgraph)
> >>
> >> # this one gives the error
> >> keggID <- "05213"
> >> tmpXML <- "testKGML1.xml"
> >> retrieveKGML(pathwayid=keggID, organism='mmu', destfile=tmpXML,
> >> method="wget")
> >> tmpGraph1 <- parseKGML2Graph(tmpXML, genesOnly=FALSE)
> >> plotKEGGgraph(tmpGraph1)
> >>
> >> # this one does not give an error, and spits out a very
complicated
> graph
> >> keggID <- "04810"
> >> tmpXML <- "testKGML2.xml"
> >> retrieveKGML(pathwayid=keggID, organism='mmu', destfile=tmpXML,
> >> method="wget")
> >> tmpGraph2 <- parseKGML2Graph(tmpXML, genesOnly=FALSE)
> >> plotKEGGgraph(tmpGraph2)
> >>
> >> Any help on why this error is cropping up would be appreciated.
> >>
> >> R version 2.11.1 (2010-05-31)
> >> i386-pc-mingw32
> >>
> >> locale:
> >> [1] LC_COLLATE=English_United States.1252
> >> [2] LC_CTYPE=English_United States.1252
> >> [3] LC_MONETARY=English_United States.1252
> >> [4] LC_NUMERIC=C
> >> [5] LC_TIME=English_United States.1252
> >>
> >> attached base packages:
> >> [1] grid stats graphics grDevices utils datasets
methods
> >> [8] base
> >>
> >> other attached packages:
> >> [1] KEGGgraph_1.4.0 Rgraphviz_1.26.0 graph_1.26.0 XML_3.1-0
> >>
> >> loaded via a namespace (and not attached):
> >> [1] tools_2.11.1
> >>
> >> Thanks in advance,
> >>
> >> -Robert
> >>
> >> Robert M. Flight, Ph.D.
> >> Bioinformatics and Biomedical Computing Laboratory
> >> University of Louisville
> >> Louisville, KY
> >>
> >> PH 502-852-0467
> >> EM robert.flight@louisville.edu
> >> EM rflight79@gmail.com
> >>
> >> Williams and Holland's Law:
> >> If enough data is collected, anything may be proven by
> >> statistical methods.
> >>
> >> _______________________________________________
> >> Bioconductor mailing list
> >> Bioconductor@stat.math.ethz.ch
> >> https://stat.ethz.ch/mailman/listinfo/bioconductor
> >> Search the archives:
> >> http://news.gmane.org/gmane.science.biology.informatics.conductor
> >>
> >
> >
> >
> > --
> > Jitao David Zhang
> > Pre-doc staff of Computational Biology and Biostatistics
> > Division of Molecular Genome Analysis
> > DKFZ, Heidelberg D-69120, Germany
> >
> > http://www.NextBioMotif.com/
> >
> > [[alternative HTML version deleted]]
> >
> > _______________________________________________
> > Bioconductor mailing list
> > Bioconductor@stat.math.ethz.ch
> > https://stat.ethz.ch/mailman/listinfo/bioconductor
> > Search the archives:
> http://news.gmane.org/gmane.science.biology.informatics.conductor
> >
>
--
Jitao David Zhang
Pre-doc staff of Computational Biology and Biostatistics
Division of Molecular Genome Analysis
DKFZ, Heidelberg D-69120, Germany
http://www.NextBioMotif.com/
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