Hi guys, we have installed R 2.12 and BioConductor on a new Mac. The installation worked fine without any errors; however, the following error is produced when trying to load Biobase: > library(Biobase) Error in dyn.load(file, DLLpath = DLLpath, ...) : unable to load shared object '/Users/eramadan/Library/R/2.12/library/Biobase/libs/x86_64/Biobase.so ': dlopen(/Users/eramadan/Library/R/2.12/library/Biobase/libs/x86_64/Biob ase.so, 6): Library not loaded: /Library/Frameworks/R.framework/Versions/2.11/Resources/lib/libR.dylib Referenced from: /Users/eramadan/Library/R/2.12/library/Biobase/libs/x86_64/Biobase.so Reason: image not found Error: package/namespace load failed for 'Biobase' The odd thing is the "2.11" in the path to libR.dylib; this does not exist and should likely be 2.12. Subsequently, all the BioConductor packages fail to load since they depend on Biobase. Please help. We are using the following configuration: > sessionInfo() R version 2.12.0 Patched (2010-10-19 r53362) Platform: x86_64-apple-darwin9.8.0/x86_64 (64-bit) locale: [1] en_US.UTF-8/en_US.UTF-8/C/C/en_US.UTF-8/en_US.UTF-8 attached base packages: [1] stats graphics grDevices utils datasets methods base loaded via a namespace (and not attached): [1] tools_2.12.0 Thanks so much, Josef and Emad -- Josef Spidlen, Ph.D. Terry Fox Laboratory, BC Cancer Agency 675 West 10th Avenue, V5Z 1L3 Vancouver, BC, Canada Tel: +1 (604) 675-8000 x 7755 http://www.terryfoxlab.ca/people/rbrinkman/josef.aspx

Hi Josef and Emad, Yes sadly our Mac binaries have this problem. Some people already reported this on the BioC-devel list: https://stat.ethz.ch/pipermail/bioc-devel/2010-October/002348.html We are currently rebuilding them and will update you when they are fixed. Thanks for your patience and sorry for the inconvenience, H. On 10/19/2010 02:20 PM, Josef Spidlen wrote: > Hi guys, > we have installed R 2.12 and BioConductor on a new Mac. The installation > worked fine without any errors; however, the following error is produced > when trying to load Biobase: > > > library(Biobase) > Error in dyn.load(file, DLLpath = DLLpath, ...) : > unable to load shared object > '/Users/eramadan/Library/R/2.12/library/Biobase/libs/x86_64/Biobase. so': > dlopen(/Users/eramadan/Library/R/2.12/library/Biobase/libs/x86_64/Bi obase.so, > 6): Library not loaded: > /Library/Frameworks/R.framework/Versions/2.11/Resources/lib/libR.dylib > Referenced from: > /Users/eramadan/Library/R/2.12/library/Biobase/libs/x86_64/Biobase.so > Reason: image not found > Error: package/namespace load failed for 'Biobase' > > The odd thing is the "2.11" in the path to libR.dylib; this does not > exist and should likely be 2.12. Subsequently, all the BioConductor > packages fail to load since they depend on Biobase. > > Please help. > > We are using the following configuration: > > sessionInfo() > R version 2.12.0 Patched (2010-10-19 r53362) > Platform: x86_64-apple-darwin9.8.0/x86_64 (64-bit) > > locale: > [1] en_US.UTF-8/en_US.UTF-8/C/C/en_US.UTF-8/en_US.UTF-8 > > attached base packages: > [1] stats graphics grDevices utils datasets methods base > > loaded via a namespace (and not attached): > [1] tools_2.12.0 > > Thanks so much, > Josef and Emad > > -- Hervé Pagès Program in Computational Biology Division of Public Health Sciences Fred Hutchinson Cancer Research Center 1100 Fairview Ave. N, M2-B876 P.O. Box 19024 Seattle, WA 98109-1024 E-mail: hpages at fhcrc.org Phone: (206) 667-5791 Fax: (206) 667-1319