Not posted/worked on R in ages. I am encountering a reproducible problem using BeadarrayUseCases from BioC downloadsite with R2.14.1. For clarity the session info, actual pasted command and full error are all pasted below. When I paste the command from the vignette into R (x64 or x32) I get "(all packages listed) ... are not available (for R version 2.14.1)". The problem was resolved by installing/using 2.14.0 instead (as the vignette was compiled in 2.14.0) meaning I can get on with my work. I just thought I should report it since it seems excessive that a minor version change would stop such a recent package from working. Especially since the advice given when installing BioC is to get the latest version. Whatever the cause may affect multiple packages meaning people would be forced to "downgrade" for some applications. Keep up the good work! Nick CMD: biocLite (c(" beadarray ", " limma ", " GEOquery ", " illuminaHumanv1 .db", 3 + " illuminaHumanv2 .db", " illuminaHumanv3 .db", " BeadArrayUseCases ")) Warning message: In getDependencies(pkgs, dependencies, available, lib) : packages ' beadarray ', ' limma ', ' GEOquery ', ' illuminaHumanv1 .db', ' illuminaHumanv2 .db', ' illuminaHumanv3 .db', ' BeadArrayUseCases ' are not available (for R version 2.14.1) R version 2.14.1 (2011-12-22) Platform: i386-pc-mingw32/i386 (32-bit) locale: [1] LC_COLLATE=English_United Kingdom.1252 [2] LC_CTYPE=English_United Kingdom.1252 [3] LC_MONETARY=English_United Kingdom.1252 [4] LC_NUMERIC=C [5] LC_TIME=English_United Kingdom.1252 attached base packages: [1] stats graphics grDevices utils datasets methods base other attached packages: [1] BiocInstaller_1.2.1 loaded via a namespace (and not attached): [1] tools_2.14.1 [[alternative HTML version deleted]]