Hi Mayte, The short answer is no. You could hypothetically create a mixture cdf that only contains probesets that are in the intersection of these three chip types and then normalize. Ben Bolstad has a page containing mixture cdfs for some arrays (http://bmbolstad.com/misc/mixtureCDF/MixtureCDF.html) but he never to my knowledge made one for the arrays you have. In general, I think you would be better off to normalize separately and then combine. Best, Jim On 4/27/2012 4:27 PM, Mayte Suarez-Farinas wrote: > Hi all, > > I have HGU133a , HGU133b chips done in the same set of samples. Additionally I have hgu133plus2 chips in a different set of samples. > Since "a+b" is almost "plus2", is tehre a way to combinethose two affybatchs ? > > Any guidance will be appreciated!! > > > > Mayte Suarez-Farinas > Research Assistant Professor, Laboratory of Investigative Dermatology > Biostatistician, Center for Clinical and Translational Science > The Rockefeller University > 1230 York Ave, Box 178, > New York, NY, 10065 > Phone: +1(212) 327-8213 > Fax: +1(212) 327-8232 > > _______________________________________________ > Bioconductor mailing list > Bioconductor at r-project.org > https://stat.ethz.ch/mailman/listinfo/bioconductor > Search the archives: http://news.gmane.org/gmane.science.biology.informatics.conductor -- James W. MacDonald, M.S. Biostatistician University of Washington Environmental and Occupational Health Sciences 4225 Roosevelt Way NE, # 100 Seattle WA 98105-6099