Jun/28/12 7:41 PM, Oren Schaedel scripsit:: > Hello everyone, > I'm new to the bioconducter list, and I have a question about DEseq: > Is it necessary to perform the FDR correction even though the variance is > estimated by the hierarchical model? I ask this because the values of > neighboring genes (hypothesis for the FDR) are used for the variance > estimation. Do we need to take into account these values again? > > > Thanks for your help > Dear Oren multiple testing adjustment is needed after an analysis with DESeq just as with any other gene-by-gene testing method. Best wishes Wolfgang Wolfgang Huber EMBL http://www.embl.de/research/units/genome_biology/huber