Fellow Bioconductor members, We would like to introduce you to our new package for calculating the necessary power statistics for RNA-Sequencing experiments. http://www.bioconductor.org/packages/devel/bioc/html/RNASeqPower.html This package can help an investigator determine how many replicates are necessary, how deep they should sequence, and explore how the coefficient of variation is the principle driver in determining whether or not a gene will be differentially expressed under different conditions of type I error, power, and effect sizes. If you have any questions regarding this software or its application, please feel free to contact me directly. Regards, Steven Hart, Ph.D. | Research Associate | Division of Biomedical Statistics and Informatics | Department of Health Sciences Research | Mayo College of Medicine | Phone: 507-538-5288 | Fax: 507-284-0360 | Hart.Steven@mayo.edu Mayo Clinic | 200 First Street SW | Rochester, MN 55905 | www.mayoclinic.org [[alternative HTML version deleted]]