Genes and Metabolites
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nooshin ▴ 300
@nooshin-5239
Last seen 5.4 years ago
Hi, I have a question, does anybody know a package in bioconductor or any tool (for Arabidopsis thaliana) that if I give a name of metabolite, I get all the genes (known so far) that involved in the reactions in which my specific metabolite is playing a role as substrate or product? Thanks a lot. Best, N.O. [[alternative HTML version deleted]]
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pj dias ▴ 60
@pj-dias-4324
Last seen 7.7 years ago
Hi. N.O. In my opinion, the best suitable tool for that objective is a network exploration software like cytoscape. 1) Install cytoscape version 2.8.3, and add the toolbox cySBML. 2) Obtain the SBML file for the metabolic reconstruction of the organism you are studying 3) search your metabolite, click in it, and then use the cytoscape option to select the adjacent nodes of selected node. That will give you the reactions your metabolites is involved. 4) By using again the option select adjacent nodes of selected node, you will obtain your gene names. Regards Pj 2013/9/12 n omranian <n_omranian@yahoo.com> > > > Hi, > > I have a question, does anybody know a package in bioconductor or any tool > (for Arabidopsis thaliana) that if I give a name of metabolite, I get all > the genes (known so far) that involved in the reactions in which my > specific metabolite is playing a role as substrate or product? > > Thanks a lot. > Best, > N.O. > [[alternative HTML version deleted]] > > _______________________________________________ > Bioconductor mailing list > Bioconductor@r-project.org > https://stat.ethz.ch/mailman/listinfo/bioconductor > Search the archives: > http://news.gmane.org/gmane.science.biology.informatics.conductor > [[alternative HTML version deleted]]
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Hi N.O., If you have not already tried already, PMN (http://www.plantcyc.org/) would be quite useful. You should find the required info in AraCyc. However, you may have to create a login and play around a bit to get right details. All the best, Avinash On 12 September 2013 05:58, Pj Dias <pjdias87@gmail.com> wrote: > Hi. N.O. > > In my opinion, the best suitable tool for that objective is a network > exploration software like cytoscape. > > 1) Install cytoscape version 2.8.3, and add the toolbox cySBML. > > 2) Obtain the SBML file for the metabolic reconstruction of the organism > you are studying > > 3) search your metabolite, click in it, and then use the cytoscape option > to select the adjacent nodes of selected node. That will give you the > reactions your metabolites is involved. > > 4) By using again the option select adjacent nodes of selected node, you > will obtain your gene names. > > Regards > > Pj > > > 2013/9/12 n omranian <n_omranian@yahoo.com> > > > > > > > Hi, > > > > I have a question, does anybody know a package in bioconductor or any > tool > > (for Arabidopsis thaliana) that if I give a name of metabolite, I get > all > > the genes (known so far) that involved in the reactions in which my > > specific metabolite is playing a role as substrate or product? > > > > Thanks a lot. > > Best, > > N.O. > > [[alternative HTML version deleted]] > > > > _______________________________________________ > > Bioconductor mailing list > > Bioconductor@r-project.org > > https://stat.ethz.ch/mailman/listinfo/bioconductor > > Search the archives: > > http://news.gmane.org/gmane.science.biology.informatics.conductor > > > > [[alternative HTML version deleted]] > > _______________________________________________ > Bioconductor mailing list > Bioconductor@r-project.org > https://stat.ethz.ch/mailman/listinfo/bioconductor > Search the archives: > http://news.gmane.org/gmane.science.biology.informatics.conductor > [[alternative HTML version deleted]]
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