Hi there, I've been working with the ComBat function in the SVA package and I've found that there seems to be a problem when trying to include numerical covariates in the model. I consistently get the error: Error in t(design) %*% design : requires numeric/complex matrix/vector arguments For example, if I run: model = model.matrix(~as.factor(Sex) + as.numeric(Age)) ComBat_dat = ComBat(gene_express, batch = BatchNums, mod = model, numCovs = 3, prior.plots = TRUE) This produces: Found 26 batches Found 1 categorical covariate(s) Found 1 continuous covariate(s) Standardizing Data across genes Error in t(design) %*% design : requires numeric/complex matrix/vector arguments However, when I use a model that only includes factors, I don't get any errors. Any ideas on what is going wrong here? Any help would be appreciated. Thanks, -- Jordan Ramsey [[alternative HTML version deleted]]