Dear group, I have log-fold changes from a set of experiments. I want see the relation between these two experiments in relation to a pathway. Can I use a fisher exact test on these two data sets to see different outcomes for two datsets on one pathway. Is this test valid only for data in a 2X2 matrix, is this valid for a 2X12K matrix (2 studies, 12K genes). I apologize if this is a wrong question to ask here. Peri.