Question: Joint test for interactions in GWASTools
0
gravatar for chintanm
4.0 years ago by
chintanm0
United States
chintanm0 wrote:

In the "GWASTools" R Package, the "assocRegression" function allows GWAS with interactions. Suppose my model is:

y ~ a + b*z + c*G + d*(z * G)

where y=RESPONSE, z=Interacting variable, and G=Genomic factor.

The "assocRegression" returns tests on the following null hypotheses {c=0} , {d=0}, and {c=0, d=0} .

Is it possible for it to also test {b=0,d=0}? This is the joint hypothesis where the interacting variable "z" has no effect (with no restriction on the non-interacting genomic effect).

Thank you.

 

gwastools • 504 views
ADD COMMENTlink modified 4.0 years ago by Stephanie M. Gogarten670 • written 4.0 years ago by chintanm0
Answer: Joint test for interactions in GWASTools
0
gravatar for Stephanie M. Gogarten
4.0 years ago by
University of Washington
Stephanie M. Gogarten670 wrote:

Sorry, assocRegression does not perform that test. If you really need it, I recommend using getGenotype to read in the genotypes and coding the test exactly as you want it.

ADD COMMENTlink written 4.0 years ago by Stephanie M. Gogarten670
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