readVcf error resulting from star * in alt allele field
1
0
Entering edit mode
@christian-ruckert-3294
Last seen 4.9 years ago
Germany
I get the following error when trying to read in a VCF file:

Error in .Call2("new_XStringSet_from_CHARACTER", ans_class, ans_elementType,  : 
  key 42 (char '*') not in lookup table

 

The problematic entry is:

3    37067095    .    ATATATTTTTT    *    11571.2    PASS    AC=1;AC_Orig=7;AF=0.5;AF_Orig=0.438;AN=2;AN_Orig=16;BaseQRankSum=-1.019;DP=2420;ExcessHet=3.01;FS=7.334;MQ=60;MQRankSum=0.356;QD=8.69;ReadPosRankSum=2.07;SOR=1.365    GT:AD:GQ:PL:SAC    0/1:121,56:99:1570,0,4899:86,35,0,0,47,9

 

The * character was introduced in VCF 4.2 to indicate that the allele is missing due to an upstream deletion.

Regards,

Christian

variantannotation • 1.6k views
ADD COMMENT
0
Entering edit mode
@valerie-obenchain-4275
Last seen 2.3 years ago
United States

Hi,

Support for '*' was added in VariantAnnotation 1.15.31 in devel. The Bioconductor 3.2 release is next week (Oct 14) at which time devel becomes release so the fix will be in both branches. If you can use devel, this is available right away with biocLite().

Valerie

ADD COMMENT
0
Entering edit mode

Hi,

I am using VariantAnnotation 1.16.1, but I get the same error:
Error in .Call2("new_XStringSet_from_CHARACTER", ans_class, ans_elementType,  :
  key 42 (char '*') not in lookup table

Do you have an idea about why it is not working, when I am using this version?

Josephine

ADD REPLY
0
Entering edit mode

Support for '*" is available in >= 1.16.0 so I'm not sure why this isn't working for you. Please show the output of sessionInfo() in the R session where you get the error.

If you can send me the file (valerie.obenchain@roswellpark.org) I can take a look.

Valerie

ADD REPLY
0
Entering edit mode

Thanks for sending the file. This was a bug and is now fixed in devel (1.17.6) and release ( 1.16.3). Both should be available via biocLite() tomorrow by noon PST or svn immediately. 

Valerie

ADD REPLY

Login before adding your answer.

Traffic: 983 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6