i would like to ask a very specific question regarding the possibility of combining arrayWeights() from limma with duplicateCorrelation(), in order to increase power for differential expression: (is this possible) and especially appropriate ? Without describing again any specific experimental information for an illustrative example, im posting a link to a specific experimental question that i would like to implement it if it is "valid" (Possible methodologies for constructing multi-level comparisons in limma)
Or alternatively, it is "more wise" to implement it in limma with a different model construction(along with some general assumptions based on various diagnostic plots and experimental design) without using duplicate correlation ??
Thank you for your consideration on this matter !!