Multiple linear regression model for DMR detection?
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enricoferrero ▴ 570
@enricoferrero-6037
Last seen 6 months ago
Switzerland

Hi,

I have paired RNA-seq data and WGBS data for a particular experiment with a complex design.

So far, I've performed differential expression analysis on the RNA-seq data using DESeq2 and a multiple linear regression model of this type:

Expression ~ Donor + Gender + CellType + Treatment

I would like to analyse the methylation data using the same linear model:

Methylation ~ Donor + Gender + CellType + Treatment

Are there any Bioconductor packages that allow me to fit a multiple linear regression model on WGBS data?

Thank you!

methylation linear model dmr bsseq biseq • 1.1k views
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