I am trying to process my Illumina 450 K methylation array data using Minfi but I keep getting the following error after using the function dmpFinder.
Error in smooth.spline(lambda, vec.p0, w = ncs.weights, df = 3) :
missing or infinite values in inputs are not allowed
In addition: Warning message:
Partial NA coefficients for 9542 probe(s)
I have tried removing the NAs, used beta threshold, tried different preprocessing methods etc. but nothing seems to work. I am fairly new to R. Any help would be highly appreciated.
Here's my session info:
R version 3.2.2 (2015-08-14)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 7 x64 (build 7601) Service Pack 1