Question: Difference between DESeq and DESeq2
0
gravatar for Biologist
3.5 years ago by
Biologist70
Biologist70 wrote:

Hi,

Can anyone please tell me what are the main differences between Deseq and Deseq2? I guess both work on same statistical test (Negative Binomial distribution).

And for my samples using DESeq package I have used function "nbinomTest" to test for differences between the base means for two conditions. How can I do the same using DESeq2 package. I haven't found any function for this. 

Thank you.

deseq deseq2 nbionormtest • 5.3k views
ADD COMMENTlink modified 3.5 years ago by Simon Anders3.6k • written 3.5 years ago by Biologist70
Answer: Difference between DESeq and DESeq2
1
gravatar for Simon Anders
3.5 years ago by
Simon Anders3.6k
Zentrum für Molekularbiologie, Universität Heidelberg
Simon Anders3.6k wrote:

For the differences in methodology (which are substantial), please see our paper. For explanations on how to do a simple two-group comparison, please see the Bioconductor RNA-Seq workflow or the DESeq2 package vignette.

ADD COMMENTlink written 3.5 years ago by Simon Anders3.6k

An elevator speech on the difference still would be useful.

ADD REPLYlink written 18 months ago by robert.h.bell0

The section of the vignette is pretty brief.

ADD REPLYlink written 18 months ago by Michael Love25k
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