Question: How does limma calculate log-ratio of fold change?

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moradzadeh_k921 •

**0**wrote:Hello everybody

I faced a problem in analysis of the data set "*GSE27274*" by *limma* package. The parameter "*Coef*" which shows "*logFC*" calculated by *limma* is different from the one I gained manually. I calculated log2 of treatment expression values average divided to control expression values average. I have not experienced this problem in analysis of other datasets. Is there any problem with my calculation?

Thank you

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modified 3.4 years ago
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Gordon Smyth ♦

**39k**• written 3.4 years ago by moradzadeh_k921 •**0**