makeVRangesFromGRanges throws coercing "factor" to "NA" error
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solo7773 ▴ 10
@solo7773-11037
Last seen 4.8 years ago

Dear all,

When I use makeVRangesFromGRanges (R package VariantAnnotation), I got the following error,

Error in as(mcols(gr)[, i], type[i]) : no method or default for coercing "factor" to "NA"

My operations shown below

> library(SomaticSignatures)
> data(ov_tcga, package = "SomaticCancerAlterations")
> ov_tcga_2_vr <- makeVRangesFromGRanges(ov_tcga, ref.field="Reference_Allele", alt.field = "Tumor_Seq_Allele2")
Error in as(mcols(gr)[, i], type[i]) :
no method or default for coercing "factor" to "NA"

Can anybody help me to solve this problem? Thank.

r packages somaticsignatures variantannotation • 822 views
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Can any body give me some advice?

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@martin-morgan-1513
Last seen 3 months ago
United States

I think this is a bug in VariantAnnotation 1.18.1 / 1.19.5. A work-around is to make the order of the columns of the GRanges match the order in the argument list

idx = match(c("Reference_Allele", "Tumor_Seq_Allele2"), names(mcols(ov_tcga)))
mcols(ov_tcga) = cbind(mcols(ov_tcga)[idx], mcols(ov_tcga)[-idx])
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Dear Martin Morgan, thank you very much. It works now.

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