org.Hs.eg.db - hg38 build?
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Brian Smith ▴ 120
@brian-smith-6197
Last seen 3.6 years ago
United States

Hi,

How can I determine which build org.Hs.eg.db based on?

 

thanks!
org.hs.eg.db • 4.0k views
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@james-w-macdonald-5106
Last seen 9 hours ago
United States
The orgDb packages don't really contain any positional annotation. They used to, but these days you will be directed to a TxDb package if you try to get positional info. And the TxDb have the build in the package name. The orgDb packages mostly contain mappings between various databases and some functional annotation, none of which is based on any build. In fact, most of that stuff is updated weekly or monthly, so the orgDb packages get outdated to a certain extent rather quickly.
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Keith Hughitt ▴ 180
@keith-hughitt-6740
Last seen 8 weeks ago
United States

The current version of org.Hs.eg.db is based on hg19:

> org.Hs.eg.db
OrgDb object:
| DBSCHEMAVERSION: 2.1
| Db type: OrgDb
| Supporting package: AnnotationDbi
| DBSCHEMA: HUMAN_DB
| ORGANISM: Homo sapiens
| SPECIES: Human
| EGSOURCEDATE: 2016-Mar14
| EGSOURCENAME: Entrez Gene
| EGSOURCEURL: ftp://ftp.ncbi.nlm.nih.gov/gene/DATA
| CENTRALID: EG
| TAXID: 9606
| GOSOURCENAME: Gene Ontology
| GOSOURCEURL: ftp://ftp.geneontology.org/pub/go/godatabase/archive/latest-lite/
| GOSOURCEDATE: 20160305
| GOEGSOURCEDATE: 2016-Mar14
| GOEGSOURCENAME: Entrez Gene
| GOEGSOURCEURL: ftp://ftp.ncbi.nlm.nih.gov/gene/DATA
| KEGGSOURCENAME: KEGG GENOME
| KEGGSOURCEURL: ftp://ftp.genome.jp/pub/kegg/genomes
| KEGGSOURCEDATE: 2011-Mar15
| GPSOURCENAME: UCSC Genome Bioinformatics (Homo sapiens)
| GPSOURCEURL: ftp://hgdownload.cse.ucsc.edu/goldenPath/hg19
| GPSOURCEDATE: 2010-Mar22
| ENSOURCEDATE: 2016-Mar9
| ENSOURCENAME: Ensembl
| ENSOURCEURL: ftp://ftp.ensembl.org/pub/current_fasta
| UPSOURCENAME: Uniprot
| UPSOURCEURL: http://www.UniProt.org/
| UPSOURCEDATE: Wed Mar 23 15:50:09 2016

Also, you may want to check out newer Homo.sapiens organism package which combines the org.db and TxDb resources into a single API.
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The only data in the orgDb packages that comes from hg19 is the outdated CHRLOC table, and as I already mentioned, any query to that table will result in a message saying you should use a TxDb package for that info. The remaining data are not based on any build, as things like an Entrez Gene ID are build agnostic. So to say it is based on any build is misleading.

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Thanks for the clarification, James! I don't think I ever fully appreciated the precise scope of the org.db packages. That explanation helps to clear some things up for me.

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