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Question: org.Hs.eg.db - hg38 build?
0
gravatar for Brian Smith
2.4 years ago by
Brian Smith120
United States
Brian Smith120 wrote:

Hi,

How can I determine which build org.Hs.eg.db based on?

 

thanks!

ADD COMMENTlink modified 2.4 years ago by Keith Hughitt120 • written 2.4 years ago by Brian Smith120
0
gravatar for James W. MacDonald
2.4 years ago by
United States
James W. MacDonald48k wrote:
The orgDb packages don't really contain any positional annotation. They used to, but these days you will be directed to a TxDb package if you try to get positional info. And the TxDb have the build in the package name. The orgDb packages mostly contain mappings between various databases and some functional annotation, none of which is based on any build. In fact, most of that stuff is updated weekly or monthly, so the orgDb packages get outdated to a certain extent rather quickly.
ADD COMMENTlink written 2.4 years ago by James W. MacDonald48k
0
gravatar for Keith Hughitt
2.4 years ago by
Keith Hughitt120
United States
Keith Hughitt120 wrote:

The current version of org.Hs.eg.db is based on hg19:

> org.Hs.eg.db
OrgDb object:
| DBSCHEMAVERSION: 2.1
| Db type: OrgDb
| Supporting package: AnnotationDbi
| DBSCHEMA: HUMAN_DB
| ORGANISM: Homo sapiens
| SPECIES: Human
| EGSOURCEDATE: 2016-Mar14
| EGSOURCENAME: Entrez Gene
| EGSOURCEURL: ftp://ftp.ncbi.nlm.nih.gov/gene/DATA
| CENTRALID: EG
| TAXID: 9606
| GOSOURCENAME: Gene Ontology
| GOSOURCEURL: ftp://ftp.geneontology.org/pub/go/godatabase/archive/latest-lite/
| GOSOURCEDATE: 20160305
| GOEGSOURCEDATE: 2016-Mar14
| GOEGSOURCENAME: Entrez Gene
| GOEGSOURCEURL: ftp://ftp.ncbi.nlm.nih.gov/gene/DATA
| KEGGSOURCENAME: KEGG GENOME
| KEGGSOURCEURL: ftp://ftp.genome.jp/pub/kegg/genomes
| KEGGSOURCEDATE: 2011-Mar15
| GPSOURCENAME: UCSC Genome Bioinformatics (Homo sapiens)
| GPSOURCEURL: ftp://hgdownload.cse.ucsc.edu/goldenPath/hg19
| GPSOURCEDATE: 2010-Mar22
| ENSOURCEDATE: 2016-Mar9
| ENSOURCENAME: Ensembl
| ENSOURCEURL: ftp://ftp.ensembl.org/pub/current_fasta
| UPSOURCENAME: Uniprot
| UPSOURCEURL: http://www.UniProt.org/
| UPSOURCEDATE: Wed Mar 23 15:50:09 2016

Also, you may want to check out newer Homo.sapiens organism package which combines the org.db and TxDb resources into a single API.

ADD COMMENTlink modified 2.4 years ago • written 2.4 years ago by Keith Hughitt120

The only data in the orgDb packages that comes from hg19 is the outdated CHRLOC table, and as I already mentioned, any query to that table will result in a message saying you should use a TxDb package for that info. The remaining data are not based on any build, as things like an Entrez Gene ID are build agnostic. So to say it is based on any build is misleading.

ADD REPLYlink written 2.4 years ago by James W. MacDonald48k

Thanks for the clarification, James! I don't think I ever fully appreciated the precise scope of the org.db packages. That explanation helps to clear some things up for me.

ADD REPLYlink written 2.4 years ago by Keith Hughitt120
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