Question: Number of tumor samples and analysis by SomaticSignature Package
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gravatar for arsala521
2.7 years ago by
arsala52110
arsala52110 wrote:

Hello

I am using SomaticSignatures package for data analysis. If I have four cancers under study should the number of samples for each cancer type be the same. I mean to ask that is this alright if for one cancer type I have data for 200 samples and for other cancer type I have data for 400 samples. Would the analysis by SomaticSignatures be reliable in such case?

Can someone kindly answer my question?

Regards 

somaticsignatures • 400 views
ADD COMMENTlink modified 2.7 years ago by Julian Gehring1.3k • written 2.7 years ago by arsala52110
Answer: Number of tumor samples and analysis by SomaticSignature Package
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gravatar for Julian Gehring
2.7 years ago by
Julian Gehring1.3k
Julian Gehring1.3k wrote:

The number of samples in each group can differ, i.e. your design of 200 vs 400 samples does not pose a problem. To account for different numbers of mutations, the motif matrix gets normalised and does not use the absolute number of variants. You can have a look at the vignette to see an example of this.

ADD COMMENTlink written 2.7 years ago by Julian Gehring1.3k

Thank you so much.

ADD REPLYlink written 2.7 years ago by arsala52110
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