Question: DSS DMLtest with different group sizes
0
3.0 years ago by
aerval0
aerval0 wrote:

Can you run the DMLtest function with different replicate group sizes? For me it fails with the following output:

Smoothing ...
Estimating dispersion for each CpG site, this will take a while ...
Error in x1 * wt1 : non-conformable arrays

if called with groups of 3 and 5 replicates.

It might not be the best idea to have different sample sizes in the first place but would also not be beneficial to exclude this additional information in the variation analysis.

Edit: btw. with groups of 3 replicates each it does not fail

dss • 431 views
modified 3.0 years ago • written 3.0 years ago by aerval0

ah, I see, there was an error in the DSS package that is not yet fixed in the release (but installing from github works)