Question: Clarifications on p-values in enrichResult objects
1
2.8 years ago by
enricoferrero570
Switzerland
enricoferrero570 wrote:

In clusterProfiler, enrichResult objects have three columns for p-values: pvalue, p.adjust and qvalue.

1. What is the difference between p.adjust and qvalue?

2. On what columns are the pvalueCutoff and qvalueCutoff filters performed?

3. if qvalueCutoff operates on column qvalue, why are rows with a NA q-value not removed?

Thanks!

modified 2.8 years ago by Guangchuang Yu1.1k • written 2.8 years ago by enricoferrero570
Answer: Clarifications on p-values in enrichResult objects
2
2.8 years ago by
Guangchuang Yu1.1k
China/Guangzhou/Southern Medical University
Guangchuang Yu1.1k wrote:

3. Sometimes it may fail to calculate qvalue and then the column will be set to NA without filtering.

Thanks! Are pvalueCutoff and qvalueCutoff combined with an AND or an OR? In other words, do both or either conditions need to be satisfied?

1

AND, both should be satisfied.