Hi all,

I have some human cancer RNA-seq data (control/treatment) , I did differential expression analysis (with CLC Genomics) and performed meta-analysis (fisher test) by metaDE package of R.

now I want to define a threshold  for FDR, but after defining a threshold (FDR  ≤ .05) Nothing left, because the smallest FDR  is 0.1651751 and the largest is 0.9999993,and Most of the numbers is around 0.98.why are they so big?