Question: SomaticSignature - Significant signature
gravatar for ksivapra
2.6 years ago by
ksivapra0 wrote:


I am using SomaticSignatures package to generate mutational signature plots for a study with a single disease. Using RSS and variance plot, I have 10 signatures generated but want to know which one of these is the most significant. Is there a way to get a p-value or something similar for the signatures. 


somaticsignatures • 490 views
ADD COMMENTlink written 2.6 years ago by ksivapra0

Can you explain in a bit more detail what you mean with "most significant", i.e. what null hypothesis you have in mind?

ADD REPLYlink written 2.5 years ago by Julian Gehring1.3k

Sure. I have 10 signatures from a single cancer study and have assigned each sample as a study by-itself to look into the profile for every sample. I could probably look into the percentage contribution plot using plotSamples method to know that. I am trying to find which one of these 10 signature is the most significant(most dominant) amongst all the samples. Is there a way to get this value with the package, besides computing  incidence or frequency of every signature and anova ?

ADD REPLYlink written 2.5 years ago by ksivapra0
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