Are broad/narrow peak comparable?
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Yuan Tian ▴ 240
@yuan-tian-13904
Last seen 3 days ago
United Kingdom

Hi:

I am using DiffBind to analysis some hMeDIP-seq data. I have called peak from MACS2 (narrow) and SICER (broad) separately. And the results can both be loaded into DiffBind. I like to generate AffinifyBinding matrix for custom downstream analysis and visualisation, as it returns nice coordinates format and normalised peak intensity value.

My question is, I can't comapre the two peak value matrixes (from AffinityBinding matrix) between narrow/broad peaks right? Since they are from different peak-caller. For example, I can't find genes have higher peak signal in gene body than gene promoter.

Best Tian

Peaks MAC2 DiffBind • 49 views
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