Is there a Bioconductor package to calculate TFs regulatory networks?
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Last seen 17 months ago

Hi all, I am looking for a tool similar to iRegulon from Cytoscape.

Basically, I would like to input a list of genes and get a plot where master regulators of that list are highlighted. The tool would have to crreate a network, calculate binding motifs, predict regulators and targets, in the genes of interest. In particular, I am looking to understand how a single transcription factor (TF) of my interest is regulating any/some of the genes of the list, so it would be useful if that could be specified, but also how other master regulators are involved and get a plot where this could be understood.

This is a plot produced with iRegulon and this more or less what I am looking for: Plot from IRegulon

Thank you in advance for your help!!

TFs Transcription regulator • 336 views

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