Job:Computational Biology Contractor - Chinook Therapeutics
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eolson • 0
Last seen 14 months ago
United States

Company: Chinook Therapeutics is a clinical-stage biotechnology company developing precision medicines for kidney diseases. Chinook’s product candidates are being investigated in rare, severe chronic kidney disorders with opportunities for well-defined clinical pathways. Chinook’s lead program is atrasentan, a phase 3 endothelin receptor antagonist for the treatment of IgA nephropathy and other proteinuric glomerular diseases. BION-1301, an anti-APRIL monoclonal antibody is being evaluated in a phase 1/2 trial for IgA nephropathy. In addition, Chinook is advancing CHK-336, an oral small molecule LDHA inhibitor for the treatment of primary hyperoxaluria, as well as research programs for other rare, severe chronic kidney diseases. Chinook is building its pipeline by leveraging insights in kidney single cell RNA sequencing, human-derived organoids, and new translational models, to discover and develop therapeutics with differentiating mechanisms of action against key kidney disease pathways. Chinook trades on Nasdaq under the ticker symbol KDNY and has locations in Vancouver, BC, Seattle, WA and Oakland, CA.

Role: Work closely with Early Discovery and Computational Biology teams to analyze genomics datasets in support of target identification and characterization. Using datasets from in vitro and in vivo model systems as well as human disease datasets work closely with Biology team to better understand mechanisms of chronic kidney disease progression.

Contact: Send CV to

Description and requirements:

Duration: 4-6 months (potential for longer term)


Location: Seattle, Vancouver, BC or remote

Rate: DOE

PhD required, minimum 2 years post PhD experience

RNA-seq experience required (scRNA-seq desirable)

Data analysis – differentially expressed genes, pathway analysis

R required (DESeq, Seurat, Bioconductor, etc.)

Python a plus

Human disease genetics experience a plus

Disease biology experience desirable (Kidney disease a plus)

Work closely with Chinook Comp Bio and Biology teams

Good oral and written communication skills

Able work independently and as part of a project team

Some experience leading a project a plus

At least 50% availability during Chinook core hours (9am-3pm PT)

Ability to occasionally travel to Seattle or Vancouver, BC a plus

Patient_stratification Multi-omics RNA-seq Kidney_Disease • 587 views

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